2. Cell Cycle/DNA Damage
  3. CDK
  4. Trilaciclib

Trilaciclib  (Synonyms: G1T28)

目录号: HY-101467 纯度: 99.32%
COA 产品使用指南

摩尔计算器

Trilaciclib (G1T28) 是一种口服有效的 CDK4/6 的抑制剂，对于 CDK4 和 CDK6 的 IC50 值分别为 1 nM 和 4 nM。Trilaciclib 能够有效抑制肿瘤细胞增殖，并减轻化疗产生的血液毒性。Trilaciclib 可减轻 5FU (HY-90006) 化疗引起的细胞凋亡和骨髓抑制。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Trilaciclib Chemical Structure

Trilaciclib Chemical Structure

CAS No. : 1374743-00-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥390
In-stock
5 mg ￥1150
In-stock
10 mg ￥1650
In-stock
50 mg ￥4000
In-stock
100 mg ￥5800
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Trilaciclib:

Trilaciclib 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trilaciclib (G1T28) is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. . Trilaciclib can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1].

IC50 & Target

IC50: 1 nM (CDK4), 4 nM (CDK6)[1]
体外研究
(In Vitro)

Trilaciclib (10-1000 nM; 24 h) 可逆地调节小鼠和犬骨髓造血干细胞和祖细胞的增殖[1]。
Trilaciclib (10-1000 nM; 24 h) 可将 CDK4/6 依赖性细胞的细胞周期阻滞在 G1 期，对HS68的EC50为 30 nM[1]。
Trilaciclib (300 nM；16 或 48 h) 可保护 CDK4/6 依赖性细胞（HS68、WM2664）免受化疗引起的损伤，并减弱化疗引起的细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trilaciclib 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HS68, WM2664 cells
Concentration: 300 nM
Incubation Time: 8h for measure γH2AX foci (DNA damage); 48 hours to measure caspase 3/7 activity (apoptosis).
Result: Produced a strong dose-dependent inhibition of HSPC proliferation within 12 hours.
Elicited a robust dose-dependent decrease in caspase 3/7 activation suggesting an attenuation of apoptosis.
Resulted a dose-dependent decrease in γH2AX foci in all DNA damaging chemotherapies tested (carboplatin, doxorubicin, etoposide, camptothecin).

Western Blot Analysis[1]

Cell Line: HS68, WM2664 cells
Concentration: 10, 30, 100, 300, 1000 nM
Incubation Time: 16 h
Result: Blocked RB phosphorylation in the RB dependent cell lines by 16 hours post exposure, while the CDK4/6-independent cell line (A2058) exhibits no RB or pRB expression. Suggesting an attenuation of chemotherapy-induced DNA damag

Cell Cycle Analysis[1]

Cell Line: HS68, WM2664 cells
Concentration: 300 nM
Incubation Time: 24 h
Result: Inhibited only CDK4/6-dependent cells, with EC50 of 30 nM for HS68 cell.
Singnificantly decreased the S phase cell numbers, increased the G1 phase cell numbers.
体内研究
(In Vivo)

Trilaciclib (50-150 mg/kg；口服；单剂量) 可保护小鼠骨髓细胞免受化疗诱导的细胞凋亡，并以剂量依赖性减轻体内化疗诱导的骨髓抑制。Trilaciclib 在 150 mg/kg 剂量下，可以减少 5FU (HY-90006) (150 mg/kg; ip) 化疗引起的 HSPC 损伤，从而加速化疗后血细胞计数的恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FVB/n female C57Bl6 mice[1]
Dosage: 50, 100, 150 mg/kg
Administration: Po; single dose; treated followed 11 or 23 hours later by a single injection of EdU (HY-118411) (100 μg; ip); mouse were euthanized 1 hour after EdU injection.
Result: Showed a dose-dependent decrease in caspase 3/7 activation.
Attenuated chemotherapy-induced myelosuppression in mice.
Clinical Trial
分子量

446.55

Formula

C24H30N8O
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 6.73 mg/mL (15.07 mM; ultrasonic and warming and adjust pH to 5 with 1 M HCL and heat to 60°C; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2394 mL 11.1970 mL 22.3939 mL
5 mM 0.4479 mL 2.2394 mL 4.4788 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.32%

COA (287 KB) HNMR (147 KB) RP-HPLC (246 KB) LCMS (102 KB)

产品使用指南 (1538 KB)
参考文献

Trilaciclib 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2394 mL 11.1970 mL 22.3939 mL 55.9848 mL
5 mM 0.4479 mL 2.2394 mL 4.4788 mL 11.1970 mL
10 mM 0.2239 mL 1.1197 mL 2.2394 mL 5.5985 mL
15 mM 0.1493 mL 0.7465 mL 1.4929 mL 3.7323 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trilaciclib1374743-00-6G1T28CDKCyclin dependent kinaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Trilaciclib
目录号：
HY-101467
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z